Assay Detail
Binding
CHEMBL643958
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Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.25 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 9.03 |
| CHEMBL51358 | — | — | 1 | 8.74 |
| CHEMBL51131 | — | — | 1 | 8.74 |
| CHEMBL300628 | — | — | 1 | 8.48 |
| CHEMBL51479 | — | — | 1 | 8.15 |
| CHEMBL300053 | — | — | 1 | 7.85 |
| CHEMBL49953 | — | — | 1 | 7.85 |
| CHEMBL541208 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL51358 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL51131 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL300628 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL51479 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL300053 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL49953 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL541208 | — | Ki | = | 70.0 | nM | 7.16 |