Assay Detail

CHEMBL643959

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Binding

Affinity towards adenosine A2 receptor

ChEMBL ↗

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Target

Adenosine A2 receptor (CHEMBL2094117) ↗

Open DB target context

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Adenosine A2 receptor (CHEMBL2094117) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Adenosine A2 receptor

CHEMBL2094117

Anchored from Assay target.

Protein identity Adenosine A2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Adenosine A2 receptor (CHEMBL2094117) ↗

Type	PROTEIN FAMILY
Organism	Rattus norvegicus

Publication

An explanation of the substituent effect of 1,3,8-trisubstituted xanthines on adenosine A1/A2 affinity.

Dooley MJ, Quinn RJ
Bioorg Med Chem Lett (1992) 2 : 1199 -1200
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.26	6.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428341	—	—	1	6.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428341	—	Ki	=	553.0	nM	6.26