Assay Detail
Binding
CHEMBL643983
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Inhibitory activity against yeast aldehyde dehydrogenase (AIDH)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Prodrugs of nitroxyl and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.79 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420451 | — | — | 1 | 5.78 |
| CHEMBL98797 | NITROSOBENZENE | — | 1 | 5.60 |
| CHEMBL101776 | METHYL (METHOXYCARBONYL)OXY(METHYLSULFONYL)CARBAMATE | — | 1 | 4.68 |
| CHEMBL99050 | ETHYL (ETHOXYCARBONYL)OXY(METHYLSULFONYL)CARBAMATE | — | 1 | 4.45 |
| CHEMBL99229 | — | — | 1 | 4.44 |
| CHEMBL98696 | — | — | 1 | 4.42 |
| CHEMBL98942 | — | — | 1 | 4.19 |
| CHEMBL319073 | — | — | 1 | - |
| CHEMBL98328 | — | — | 1 | - |
| CHEMBL95922 | — | — | 1 | - |
| CHEMBL318140 | METHYL METHOXY(METHYLSULFONYL)CARBAMATE | — | 1 | - |
| CHEMBL97966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420451 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL98797 | NITROSOBENZENE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL101776 | METHYL (METHOXYCARBONYL)OXY(METHYLSULFONYL)CARBAMATE | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL99050 | ETHYL (ETHOXYCARBONYL)OXY(METHYLSULFONYL)CARBAMATE | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL99229 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL98696 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL98942 | — | IC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL319073 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL98328 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL95922 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL318140 | METHYL METHOXY(METHYLSULFONYL)CARBAMATE | IC50 | > | 1000000.0 | nM | - |
| CHEMBL97966 | — | IC50 | > | 1000000.0 | nM | - |