Assay Detail
Binding
CHEMBL644101
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Inhibitory activity against human erythrocyte acetylcholinesterase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.44 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 8.05 |
| CHEMBL59782 | — | — | 1 | 7.89 |
| CHEMBL61715 | — | — | 1 | 7.55 |
| CHEMBL61561 | — | — | 1 | 7.35 |
| CHEMBL61850 | — | — | 1 | 7.18 |
| CHEMBL61533 | — | — | 1 | 7.06 |
| CHEMBL60119 | — | — | 1 | 7.00 |
| CHEMBL61221 | — | — | 1 | 6.89 |
| CHEMBL59628 | — | — | 1 | 6.77 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.60 |
| CHEMBL294525 | — | — | 1 | 6.54 |
| CHEMBL302842 | — | — | 1 | 6.46 |
| CHEMBL61849 | — | — | 1 | 6.41 |
| CHEMBL61986 | — | — | 1 | 6.34 |
| CHEMBL61930 | — | — | 1 | 6.33 |
| CHEMBL62084 | — | — | 1 | 6.26 |
| CHEMBL64465 | — | — | 1 | 6.12 |
| CHEMBL418643 | — | — | 1 | 5.80 |
| CHEMBL59977 | — | — | 1 | 5.52 |
| CHEMBL64815 | — | — | 1 | 5.43 |
| CHEMBL61486 | — | — | 1 | 5.42 |
| CHEMBL61506 | — | — | 1 | 5.32 |
| CHEMBL61929 | — | — | 1 | 5.28 |
| CHEMBL62085 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL59782 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL61715 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL61561 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL61850 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL61533 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL60119 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL61221 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL59628 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL95 | TACRINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL294525 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL302842 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL61849 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL61986 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL61930 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL62084 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL64465 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL418643 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL59977 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL64815 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL61486 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL61506 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL61929 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL62085 | — | IC50 | = | 8100.0 | nM | 5.09 |