Assay Detail
Binding
CHEMBL644104
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In vitro inhibition of human erythrocyte Acetylcholinesterase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.87 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340427 | XANTHOSTIGMINE | — | 1 | 9.52 |
| CHEMBL543655 | — | — | 1 | 9.49 |
| CHEMBL124933 | — | — | 1 | 8.85 |
| CHEMBL544592 | — | — | 1 | 8.27 |
| CHEMBL557405 | — | — | 1 | 8.17 |
| CHEMBL542467 | — | — | 1 | 7.93 |
| CHEMBL540833 | — | — | 1 | 7.91 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.85 |
| CHEMBL340228 | — | — | 1 | 7.68 |
| CHEMBL544823 | — | — | 1 | 7.66 |
| CHEMBL544126 | — | — | 1 | 7.61 |
| CHEMBL340171 | — | — | 1 | 7.58 |
| CHEMBL127465 | — | — | 1 | 7.56 |
| CHEMBL127857 | — | — | 1 | 7.53 |
| CHEMBL124156 | — | — | 1 | 7.26 |
| CHEMBL539045 | — | — | 1 | 7.10 |
| CHEMBL542220 | — | — | 1 | 7.08 |
| CHEMBL553803 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340427 | XANTHOSTIGMINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL543655 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL124933 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL544592 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL557405 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL542467 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL540833 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL340228 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL544823 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL544126 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL340171 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL127465 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL127857 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL124156 | — | IC50 | = | 54.6 | nM | 7.26 |
| CHEMBL539045 | — | IC50 | = | 79.6 | nM | 7.10 |
| CHEMBL542220 | — | IC50 | = | 82.6 | nM | 7.08 |
| CHEMBL553803 | — | IC50 | = | 210.0 | nM | 6.68 |