Assay Detail
Binding
CHEMBL644105
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Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytes
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.42 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93936 | — | — | 1 | 9.10 |
| CHEMBL92736 | — | — | 1 | 8.55 |
| CHEMBL91291 | — | — | 1 | 8.24 |
| CHEMBL93619 | — | — | 1 | 8.15 |
| CHEMBL94186 | — | — | 1 | 8.14 |
| CHEMBL433379 | — | — | 1 | 8.11 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.10 |
| CHEMBL418955 | — | — | 1 | 8.08 |
| CHEMBL92663 | — | — | 1 | 8.06 |
| CHEMBL93123 | — | — | 1 | 8.03 |
| CHEMBL92955 | — | — | 1 | 7.85 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.72 |
| CHEMBL420625 | — | — | 1 | 7.70 |
| CHEMBL92463 | — | — | 1 | 7.58 |
| CHEMBL330004 | — | — | 1 | 7.30 |
| CHEMBL92460 | — | — | 1 | 7.26 |
| CHEMBL328102 | — | — | 1 | 7.00 |
| CHEMBL92775 | — | — | 1 | 7.00 |
| CHEMBL92958 | — | — | 1 | 6.92 |
| CHEMBL96246 | — | — | 1 | 6.68 |
| CHEMBL92142 | — | — | 1 | 6.66 |
| CHEMBL92629 | — | — | 1 | 6.50 |
| CHEMBL329531 | — | — | 1 | 6.47 |
| CHEMBL328715 | — | — | 1 | 6.09 |
| CHEMBL93241 | — | — | 1 | 6.05 |
| CHEMBL94059 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93936 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL92736 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL91291 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL93619 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL94186 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL433379 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL418955 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL92663 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL93123 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL92955 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL420625 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL92463 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL330004 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL92460 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL328102 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL92775 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL92958 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL96246 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL92142 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL92629 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL329531 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL328715 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL93241 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL94059 | — | IC50 | = | 2600.0 | nM | 5.58 |