Assay Detail
Binding
CHEMBL644109
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In vitro inhibition of acetylcholinesterase isolated from human erythrocytes.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Physical parameters for brian uptake: optimizing log P, log D and pKa of T H A
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.35 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134057 | — | — | 1 | 7.41 |
| CHEMBL130373 | — | — | 1 | 7.38 |
| CHEMBL132030 | — | — | 1 | 7.11 |
| CHEMBL133906 | — | — | 1 | 7.00 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.84 |
| CHEMBL132619 | — | — | 1 | 6.82 |
| CHEMBL132260 | — | — | 1 | 6.58 |
| CHEMBL337453 | — | — | 1 | 6.50 |
| CHEMBL133520 | — | — | 1 | 6.47 |
| CHEMBL263198 | OCTAAMINOACRIDINE | 3.0 | 1 | 6.44 |
| CHEMBL133448 | — | — | 1 | 6.37 |
| CHEMBL436367 | — | — | 1 | 6.34 |
| CHEMBL134154 | — | — | 1 | 6.22 |
| CHEMBL132365 | — | — | 1 | 6.21 |
| CHEMBL130880 | IPIDACRINE | 2.0 | 1 | 6.18 |
| CHEMBL335922 | — | — | 1 | 5.95 |
| CHEMBL130427 | — | — | 1 | 5.58 |
| CHEMBL62084 | — | — | 1 | 5.43 |
| CHEMBL133441 | — | — | 1 | 5.20 |
| CHEMBL134240 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134057 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL130373 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL132030 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL133906 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL95 | TACRINE | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL132619 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL132260 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL337453 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL133520 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL263198 | OCTAAMINOACRIDINE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL133448 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL436367 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL134154 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL132365 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL130880 | IPIDACRINE | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL335922 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL130427 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL62084 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL133441 | — | IC50 | = | 6262.0 | nM | 5.20 |
| CHEMBL134240 | — | IC50 | = | 9810.0 | nM | 5.01 |