Assay Detail
Binding
CHEMBL644116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% of acetylcholinesterase (AChE) in human erythrocyte(RBC).
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.62 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33332 | — | — | 1 | 5.42 |
| CHEMBL146158 | — | — | 1 | 5.11 |
| CHEMBL33101 | — | — | 1 | 5.08 |
| CHEMBL32768 | — | — | 1 | 5.02 |
| CHEMBL32585 | — | — | 1 | 4.94 |
| CHEMBL34000 | — | — | 1 | 4.67 |
| CHEMBL149230 | — | — | 1 | 4.62 |
| CHEMBL147968 | — | — | 1 | 4.60 |
| CHEMBL357843 | — | — | 1 | 4.58 |
| CHEMBL416772 | — | — | 1 | 4.56 |
| CHEMBL147213 | — | — | 1 | 4.49 |
| CHEMBL147793 | — | — | 1 | 4.48 |
| CHEMBL538352 | — | — | 1 | 4.42 |
| CHEMBL359412 | — | — | 1 | 4.38 |
| CHEMBL288316 | — | — | 1 | 4.31 |
| CHEMBL284692 | — | — | 1 | 4.25 |
| CHEMBL145971 | — | — | 1 | 4.25 |
| CHEMBL33051 | — | — | 1 | 4.05 |
| CHEMBL539108 | — | — | 1 | - |
| CHEMBL149427 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
| CHEMBL358323 | — | — | 1 | - |
| CHEMBL289890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33332 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL146158 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL33101 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL32768 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL32585 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL34000 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL149230 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL147968 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL357843 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL416772 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL147213 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL147793 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL538352 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL359412 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL288316 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL284692 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL145971 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL33051 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL539108 | — | IC50 | = | 339600.0 | nM | - |
| CHEMBL149427 | — | IC50 | = | 123000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | IC50 | = | 366000.0 | nM | - |
| CHEMBL358323 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL289890 | — | IC50 | = | 134000.0 | nM | - |