Assay Detail
Binding
CHEMBL644131
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Binding affinity towards Alpha-1 adrenergic receptor binding site using [3H]prazosin.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.28 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59940 | — | — | 1 | 8.57 |
| CHEMBL61747 | — | — | 1 | 7.96 |
| CHEMBL279586 | — | — | 1 | 7.92 |
| CHEMBL59335 | — | — | 1 | 7.85 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.75 |
| CHEMBL60267 | — | — | 1 | 7.70 |
| CHEMBL42228 | — | — | 1 | 7.68 |
| CHEMBL64344 | — | — | 1 | 7.62 |
| CHEMBL59464 | — | — | 1 | 7.52 |
| CHEMBL61539 | — | — | 1 | 6.66 |
| CHEMBL62994 | — | — | 1 | 6.46 |
| CHEMBL416506 | — | — | 1 | 6.38 |
| CHEMBL303336 | — | — | 1 | 6.00 |
| CHEMBL60859 | BMY-14802 | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59940 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL61747 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL279586 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL59335 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL60267 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL42228 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL64344 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL59464 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL61539 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL62994 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL416506 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL303336 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 1500.0 | nM | 5.82 |