Assay Detail
Binding
CHEMBL644192
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Binding affinity against AMPA receptor using [3H]- AMPA radioligand
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Homology modeling of the ampa receptor: A quantitative predictive tool for the design of novel antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.15 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 7.28 |
| CHEMBL293206 | — | — | 1 | 7.10 |
| CHEMBL122054 | — | — | 1 | 6.82 |
| CHEMBL32908 | — | — | 1 | 6.82 |
| CHEMBL121771 | — | — | 1 | 6.78 |
| CHEMBL155265 | DNQX | — | 1 | 6.70 |
| CHEMBL9790 | — | — | 1 | 6.47 |
| CHEMBL33751 | — | — | 1 | 6.24 |
| CHEMBL286103 | — | — | 1 | 6.20 |
| CHEMBL330795 | — | — | 1 | 6.16 |
| CHEMBL32123 | — | — | 1 | 5.87 |
| CHEMBL23044 | — | — | 1 | 5.70 |
| CHEMBL607705 | — | — | 1 | 5.14 |
| CHEMBL341000 | — | — | 1 | 4.62 |
| CHEMBL122559 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL293206 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL122054 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL32908 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL121771 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL155265 | DNQX | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL9790 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL33751 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL286103 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL330795 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL32123 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL23044 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL607705 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL341000 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL122559 | — | IC50 | = | 44000.0 | nM | 4.36 |