Compound Detail
CHEMBL341000
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL341000 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OWVOPDLAKSFZPS-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
217.2
MW (Da)
1.40
ALogP
5
HBA
3
HBD
78.3
PSA (Ų)
0.62
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 5.05 | 5.05 | 8900.0 | 2 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.62 | 4.62 | 24000.0 | 2 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 4.62 | 4.62 | 24000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate | IC50 | = | 8900.0 | nM | 5.05 | Binding affinity for the ionotropic glutamate receptor kainate in rat brain syna... | 7562904 |
| Glutamate receptor ionotropic, kainate | IC50 | = | 8900.0 | nM | 5.05 | Binding affinity for the ionotropic glutamate receptor kainate in rat brain syna... | 7562904 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 24000.0 | nM | 4.62 | Binding affinity was determined against ionotropic glutamate receptor AMPA in ra... | 7562904 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 24000.0 | nM | 4.62 | Binding affinity was determined against ionotropic glutamate receptor AMPA in ra... | 7562904 |
| Glutamate receptor ionotropic AMPA | IC50 | = | 24000.0 | nM | 4.62 | Binding affinity against AMPA receptor using [3H]- AMPA radioligand | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7562904 | 10.1021/jm00019a003 | Glutamate receptor ionotropic, AMPA | 2 |
| 7562904 | 10.1021/jm00019a003 | Glutamate receptor ionotropic, kainate | 2 |
| - | 10.1016/S0960-894X(97)00239-4 | Glutamate receptor ionotropic AMPA | 1 |
Data from ChEMBL 36 via Core Engine