Assay Detail
Binding
CHEMBL644200
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Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)
41
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
AMP deaminase inhibitors. 2. Initial discovery of a non-nucleotide transition-state inhibitor series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 5.23 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36045 | — | — | 1 | 6.52 |
| CHEMBL35929 | — | — | 1 | 6.39 |
| CHEMBL290887 | — | — | 2 | 6.19 |
| CHEMBL38113 | — | — | 1 | 6.10 |
| CHEMBL417506 | — | — | 1 | 6.07 |
| CHEMBL284799 | — | — | 1 | 6.04 |
| CHEMBL37713 | — | — | 1 | 6.01 |
| CHEMBL289052 | — | — | 1 | 5.96 |
| CHEMBL433444 | — | — | 1 | 5.85 |
| CHEMBL37142 | — | — | 1 | 5.77 |
| CHEMBL288348 | — | — | 1 | 5.68 |
| CHEMBL38002 | — | — | 1 | 5.62 |
| CHEMBL37641 | — | — | 1 | 5.52 |
| CHEMBL289823 | — | — | 1 | 5.42 |
| CHEMBL37028 | — | — | 1 | 5.38 |
| CHEMBL36046 | — | — | 1 | 5.22 |
| CHEMBL291112 | — | — | 1 | 5.09 |
| CHEMBL288266 | — | — | 1 | 5.02 |
| CHEMBL34848 | — | — | 1 | 5.01 |
| CHEMBL37135 | — | — | 1 | 5.00 |
| CHEMBL37246 | — | — | 1 | 4.70 |
| CHEMBL35767 | — | — | 1 | 4.46 |
| CHEMBL34373 | — | — | 1 | 4.44 |
| CHEMBL285450 | — | — | 1 | 4.36 |
| CHEMBL37531 | — | — | 1 | 4.28 |
| CHEMBL37053 | — | — | 1 | 4.26 |
| CHEMBL34434 | — | — | 1 | 4.26 |
| CHEMBL37174 | — | — | 1 | 4.20 |
| CHEMBL285201 | — | — | 1 | 4.19 |
| CHEMBL288438 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36045 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL35929 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL290887 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL38113 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL290887 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL417506 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL284799 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL37713 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL289052 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL433444 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL37142 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL288348 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL38002 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL37641 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL289823 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL37028 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL36046 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL291112 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL288266 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL34848 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL37135 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL37246 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL35767 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL34373 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL285450 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL37531 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL34434 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL37053 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL37174 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL285201 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL288438 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL290339 | — | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL33894 | — | Ki | > | 125000.0 | nM | - |
| CHEMBL36879 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL34128 | — | Ki | > | 125000.0 | nM | - |
| CHEMBL35156 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL36692 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL36488 | — | Ki | > | 125000.0 | nM | - |
| CHEMBL36951 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL289010 | — | Ki | > | 125000.0 | nM | - |
| CHEMBL37640 | — | Ki | > | 125000.0 | nM | - |