Assay Detail
Binding
CHEMBL644297
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Inhibitory activity against aldose reductase in rat lens
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Relative structure-inhibition analyses of the N-benzoyl and N-(phenylsulfonyl) amino acid aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.08 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.72 |
| CHEMBL302057 | — | — | 1 | 6.62 |
| CHEMBL69716 | — | — | 1 | 6.25 |
| CHEMBL305251 | — | — | 1 | 5.55 |
| CHEMBL308898 | — | — | 1 | 5.50 |
| CHEMBL69549 | — | — | 1 | 5.43 |
| CHEMBL273228 | — | — | 1 | 5.20 |
| CHEMBL66711 | — | — | 1 | 5.17 |
| CHEMBL66216 | — | — | 1 | 5.09 |
| CHEMBL266688 | — | — | 1 | 5.07 |
| CHEMBL308007 | — | — | 1 | 5.06 |
| CHEMBL302999 | — | — | 1 | 5.02 |
| CHEMBL67361 | — | — | 1 | 4.96 |
| CHEMBL67330 | — | — | 1 | 4.92 |
| CHEMBL67014 | — | — | 1 | 4.89 |
| CHEMBL67731 | — | — | 1 | 4.72 |
| CHEMBL305492 | — | — | 1 | 4.72 |
| CHEMBL69688 | — | — | 1 | 4.68 |
| CHEMBL66391 | — | — | 1 | 4.64 |
| CHEMBL68391 | — | — | 1 | 4.58 |
| CHEMBL66895 | — | — | 1 | 4.40 |
| CHEMBL67410 | — | — | 1 | 4.35 |
| CHEMBL67215 | — | — | 1 | 4.31 |
| CHEMBL8798 | — | — | 1 | 4.16 |
| CHEMBL461 | HIPPURIC ACID | — | 1 | - |
| CHEMBL306898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL302057 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL69716 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL305251 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL308898 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL69549 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL273228 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL66711 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL66216 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL266688 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL308007 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL302999 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL67361 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL67330 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL67014 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL67731 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL305492 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL69688 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL66391 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL68391 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL66895 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL67410 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL67215 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL8798 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL461 | HIPPURIC ACID | IC50 | = | 330000.0 | nM | - |
| CHEMBL306898 | — | IC50 | = | 220000.0 | nM | - |