Assay Detail
Binding
CHEMBL644303
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Tested for in vitro inhibition activity against rat Aldose reductase (AR)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 7.46 |
| CHEMBL84060 | (R,S)-FIDARESTAT | — | 1 | 6.24 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL84060 | (R,S)-FIDARESTAT | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL266497 | SORBINIL | IC50 | = | 900.0 | nM | 6.05 |