Assay Detail
Binding
CHEMBL644305
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In vitro inhibition of Aldose reductase (AR) from rat lens (RL)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 8.70 |
| CHEMBL418832 | — | — | 1 | 8.30 |
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 8.05 |
| CHEMBL327139 | — | — | 1 | 7.75 |
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 7.70 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 7.00 |
| CHEMBL324907 | — | — | 1 | 6.77 |
| CHEMBL326920 | — | — | 1 | 6.63 |
| CHEMBL325136 | — | — | 1 | 5.72 |
| CHEMBL109865 | — | — | 1 | - |
| CHEMBL322815 | — | — | 1 | - |
| CHEMBL110661 | — | — | 1 | - |
| CHEMBL325596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL418832 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL269455 | IMIRESTAT | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL327139 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL7679 | PONALRESTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL266497 | SORBINIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL324907 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL326920 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL325136 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL109865 | — | IC50 | = | 6150000.0 | nM | - |
| CHEMBL322815 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL110661 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL325596 | — | IC50 | = | 2370000.0 | nM | - |