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Assay Detail

CHEMBL644310

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.
Jagtap PG, Chen Z, Szabó C, Klotz KN.
Bioorg Med Chem Lett (2004) 14 : 1495 -1498
PubMed 15006389 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 6.79 9.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL284969 1 9.08
CHEMBL279391 1 7.68
CHEMBL36098 1 7.50
CHEMBL285251 1 7.15
CHEMBL36160 1 6.68
CHEMBL36786 1 6.60
CHEMBL36789 1 6.47
CHEMBL289982 1 6.37
CHEMBL36320 1 6.13
CHEMBL288258 1 5.79
CHEMBL36734 1 5.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL284969 Ki = 0.83 nM 9.08
CHEMBL279391 Ki = 20.7 nM 7.68
CHEMBL36098 Ki = 31.8 nM 7.50
CHEMBL285251 Ki = 70.7 nM 7.15
CHEMBL36160 Ki = 207.0 nM 6.68
CHEMBL36786 Ki = 252.0 nM 6.60
CHEMBL36789 Ki = 342.0 nM 6.47
CHEMBL289982 Ki = 432.0 nM 6.37
CHEMBL36320 Ki = 733.0 nM 6.13
CHEMBL288258 Ki = 1620.0 nM 5.79
CHEMBL36734 Ki = 5450.0 nM 5.26