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Assay Detail

CHEMBL644413

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Binding
In vitro inhibitory activity against Angiotensin I converting enzyme
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL4074)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids.
Menard PR, Suh JT, Jones H, Loev B, Neiss ES, Wilde J, Schwab A, Mann WS.
J Med Chem (1985) 28 : 328 -332
PubMed 2983075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 10.25 10.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113612 1 10.68
CHEMBL112589 1 10.68
CHEMBL324898 1 10.60
CHEMBL323879 1 10.55
CHEMBL112922 1 10.10
CHEMBL324676 1 10.00
CHEMBL324703 1 10.00
CHEMBL115153 1 10.00
CHEMBL114018 1 10.00
CHEMBL325305 1 9.92
CHEMBL111976 1 -
CHEMBL112168 1 -
CHEMBL112477 1 -
CHEMBL1560 CAPTOPRIL 4.0 1 -
CHEMBL325659 1 -
CHEMBL114242 1 -
CHEMBL112545 1 -
CHEMBL113276 1 -
CHEMBL263056 1 -
CHEMBL112630 1 -
CHEMBL324242 1 -
CHEMBL326137 1 -
CHEMBL113315 1 -
CHEMBL114294 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113612 IC50 = 0.021 nM 10.68
CHEMBL112589 IC50 = 0.021 nM 10.68
CHEMBL324898 IC50 = 0.025 nM 10.60
CHEMBL323879 IC50 = 0.028 nM 10.55
CHEMBL112922 IC50 = 0.08 nM 10.10
CHEMBL324676 IC50 = 0.1 nM 10.00
CHEMBL324703 IC50 = 0.1 nM 10.00
CHEMBL115153 IC50 = 0.1 nM 10.00
CHEMBL114018 IC50 = 0.1 nM 10.00
CHEMBL325305 IC50 = 0.12 nM 9.92
CHEMBL111976 IC50 > 0.1 nM -
CHEMBL112168 IC50 = 0.0048 nM -
CHEMBL112477 IC50 = 0.0091 nM -
CHEMBL1560 CAPTOPRIL IC50 = 2.7e-05 nM -
CHEMBL325659 IC50 = 0.00055 nM -
CHEMBL114242 IC50 = 0.0006 nM -
CHEMBL112545 IC50 > 0.1 nM -
CHEMBL113276 IC50 = 0.00038 nM -
CHEMBL263056 IC50 = 0.00068 nM -
CHEMBL112630 IC50 > 0.1 nM -
CHEMBL324242 IC50 = 0.0046 nM -
CHEMBL326137 IC50 = 0.00028 nM -
CHEMBL113315 IC50 = 0.0022 nM -
CHEMBL114294 IC50 = 0.0041 nM -