Assay Detail
Binding
CHEMBL644415
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3
69
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 69 | 6.82 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160361 | — | — | 1 | 8.30 |
| CHEMBL1907938 | — | — | 1 | 7.80 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.77 |
| CHEMBL348040 | — | — | 1 | 7.75 |
| CHEMBL23523 | — | — | 1 | 7.75 |
| CHEMBL346255 | — | — | 1 | 7.72 |
| CHEMBL346561 | — | — | 2 | 7.70 |
| CHEMBL23727 | — | — | 1 | 7.64 |
| CHEMBL158962 | — | — | 1 | 7.52 |
| CHEMBL23841 | — | — | 1 | 7.51 |
| CHEMBL278348 | — | — | 1 | 7.51 |
| CHEMBL345858 | — | — | 1 | 7.50 |
| CHEMBL23641 | — | — | 1 | 7.48 |
| CHEMBL23518 | — | — | 1 | 7.46 |
| CHEMBL422013 | — | — | 1 | 7.36 |
| CHEMBL350484 | — | — | 1 | 7.36 |
| CHEMBL406430 | — | — | 1 | 7.35 |
| CHEMBL347259 | — | — | 1 | 7.32 |
| CHEMBL159075 | — | — | 1 | 7.29 |
| CHEMBL422535 | — | — | 1 | 7.26 |
| CHEMBL346588 | — | — | 1 | 7.26 |
| CHEMBL350258 | — | — | 1 | 7.22 |
| CHEMBL347447 | — | — | 1 | 7.19 |
| CHEMBL346495 | — | — | 1 | 7.14 |
| CHEMBL348043 | — | — | 1 | 7.12 |
| CHEMBL345619 | — | — | 1 | 7.12 |
| CHEMBL160689 | — | — | 1 | 7.12 |
| CHEMBL158972 | — | — | 1 | 7.10 |
| CHEMBL160770 | — | — | 1 | 7.09 |
| CHEMBL158673 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160361 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1907938 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL23523 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL348040 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL346255 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL346561 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL23727 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL158962 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL278348 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL23841 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL345858 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL23641 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL23518 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL422013 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL350484 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL406430 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL347259 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL159075 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL346561 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL346588 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL422535 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL350258 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL347447 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL346495 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL160689 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL345619 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL348043 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL158972 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL160770 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL158673 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL350718 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL347635 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL158994 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL346535 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL347633 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL160927 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL159000 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL347853 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL160567 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL158617 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL284139 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL157543 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL160473 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL160985 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL159151 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL346254 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL345692 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL554712 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL26338 | — | IC50 | = | 300.0 | nM | 6.52 |