Assay Detail
Binding
CHEMBL644417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rabbit lung Angiotensin I converting enzyme with 5 mM hippuryl-histidyl-leucine as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.93 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302181 | — | — | 1 | 8.55 |
| CHEMBL300560 | — | — | 1 | 8.47 |
| CHEMBL300841 | TEMOCAPRILAT | 2.0 | 1 | 8.44 |
| CHEMBL59172 | — | — | 1 | 8.43 |
| CHEMBL293765 | — | — | 1 | 8.39 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.24 |
| CHEMBL61439 | — | — | 1 | 7.45 |
| CHEMBL60108 | — | — | 1 | 7.19 |
| CHEMBL292565 | — | — | 1 | 7.11 |
| CHEMBL291810 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302181 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL300560 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL300841 | TEMOCAPRILAT | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL59172 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL293765 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL61439 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL60108 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL292565 | — | IC50 | = | 78.2 | nM | 7.11 |
| CHEMBL291810 | — | IC50 | = | 86.9 | nM | 7.06 |