Assay Detail
Functional
CHEMBL644525
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Effective concentration for retinoic acid receptor RAR alpha transcriptional activation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of retinoic acid receptor-alpha specific amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69367 | — | — | 1 | 8.70 |
| CHEMBL326911 | — | — | 1 | 8.10 |
| CHEMBL106527 | — | — | 1 | 7.03 |
| CHEMBL107054 | — | — | 1 | 6.95 |
| CHEMBL107430 | NRX195183 | 2.0 | 1 | 6.70 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.62 |
| CHEMBL439780 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69367 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL326911 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL106527 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL107054 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL107430 | NRX195183 | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL38 | TRETINOIN | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL439780 | — | EC50 | = | 290.0 | nM | 6.54 |