Compound Detail
CHEMBL107430
NRX195183 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL107430 |
| Name | NRX195183 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | PNAWUIKCVQSLFG-UHFFFAOYSA-N |
8
Targets
9
Activities
3
Assay Types
0
PK Parameters
19
Publications
8
Known Names
1
Indications
1
Mechanisms
Molecular Properties
437.9
MW (Da)
5.62
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.58
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Retinoic acid receptor alpha agonist | AGONIST | Retinoic acid receptor alpha | ✓ | ✓ |
Indications
Leukemia, Promyelocytic, Acute
Activity Summary
IC50 7 meas. best 8.85
EC50 1 meas. best 6.7
Kd 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| T47D CHEMBL614361 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Retinoic acid receptor alpha CHEMBL2055 | Kd | 8.52 | 8.52 | 3.0 | 1 |
| SK-BR-3 CHEMBL613834 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Retinoic acid receptor alpha CHEMBL2055 | EC50 | 6.7 | 6.7 | 200.0 | 1 |
| Cytochrome P450 2D6 CHEMBL289 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Cytochrome P450 1A2 CHEMBL3356 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine