Assay Detail

CHEMBL815636

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Functional

Inhibition of ER positive human breast cancer cell T-47D proliferation

ChEMBL ↗

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Target

T47D (CHEMBL614361) ↗

Open DB target context

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Primary target T47D

CHEMBL614361

Anchored from Assay target.

Protein identity T47D

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	T47D
Confidence	1 — Organism
Curated By	Expert

Target

T47D (CHEMBL614361) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and biological activity of retinoic acid receptor-alpha specific amides.

Beard RL, Duong TT, Teng M, Klein ES, Standevan AM, Chandraratna RA.
Bioorg Med Chem Lett (2002) 12 : 3145 -3148
PubMed 12372520 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.78	8.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL107430	NRX195183	2.0	1	8.85
CHEMBL38	TRETINOIN	4.0	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL107430	NRX195183	IC50	=	1.4	nM	8.85
CHEMBL38	TRETINOIN	IC50	=	200.0	nM	6.70