Assay Detail

CHEMBL802894

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Functional

Inhibition of ER-negative human breast cancer cell SK-BR-3 proliferation

ChEMBL ↗

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Target

SK-BR-3 (CHEMBL613834) ↗

Open DB target context

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SK-BR-3 (CHEMBL613834) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SK-BR-3

CHEMBL613834

Anchored from Assay target.

Protein identity SK-BR-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SK-BR-3
Confidence	1 — Organism
Curated By	Expert

Target

SK-BR-3 (CHEMBL613834) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and biological activity of retinoic acid receptor-alpha specific amides.

Beard RL, Duong TT, Teng M, Klein ES, Standevan AM, Chandraratna RA.
Bioorg Med Chem Lett (2002) 12 : 3145 -3148
PubMed 12372520 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.37	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38	TRETINOIN	4.0	1	8.77
CHEMBL107430	NRX195183	2.0	1	7.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38	TRETINOIN	IC50	=	1.7	nM	8.77
CHEMBL107430	NRX195183	IC50	=	11.0	nM	7.96