Assay Detail
Functional
CHEMBL644534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Dopamine sensitive adenylate cyclase in rats
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.13 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552736 | — | — | 1 | 6.62 |
| CHEMBL369006 | — | — | 1 | 6.44 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 5.89 |
| CHEMBL541633 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552736 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL369006 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL541633 | — | IC50 | = | 2700.0 | nM | 5.57 |