Assay Detail
Functional
CHEMBL644561
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Antagonism against Alpha-1 adrenergic receptor of rat aorta
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, biological in vitro evaluation and stereoselectivity of ondansetron analogues: novel 5-HT2A receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 9.07 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 10.38 |
| CHEMBL161065 | — | — | 1 | 8.75 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Kd | = | 0.04169 | nM | 10.38 |
| CHEMBL161065 | — | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL51 | KETANSERIN | Kd | = | 8.128 | nM | 8.09 |