Assay Detail
Binding
CHEMBL644574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]clonidine from alpha-2 adrenergic receptor in rat brain homogenates in vitro
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.78 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545646 | — | — | 1 | 7.92 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | -1.0 | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545646 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL553031 | NAPAMEZOLE HYDROCHLORIDE | Ki | = | 23.0 | nM | 7.64 |