Assay Detail
Binding
CHEMBL644577
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Compound was evaluated for inhibition of porcine plasma Angiotensin I converting enzyme by using fluorometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10521 | — | — | 1 | 8.52 |
| CHEMBL274550 | — | — | 1 | 8.15 |
| CHEMBL435360 | — | — | 1 | 7.16 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10521 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL274550 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL435360 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 300.0 | nM | 6.52 |