Assay Detail
Binding
CHEMBL644580
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Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Type-1 angiotensin II receptor B (CHEMBL263) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.47 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.30 |
| CHEMBL301705 | — | — | 1 | 7.70 |
| CHEMBL48824 | — | — | 1 | 7.66 |
| CHEMBL299130 | — | — | 1 | 7.62 |
| CHEMBL297653 | — | — | 1 | 7.57 |
| CHEMBL48363 | — | — | 1 | 7.22 |
| CHEMBL48195 | — | — | 1 | 7.10 |
| CHEMBL49170 | — | — | 1 | 7.04 |
| CHEMBL45659 | — | — | 1 | 6.85 |
| CHEMBL262958 | — | — | 1 | 6.85 |
| CHEMBL48168 | — | — | 1 | 6.85 |
| CHEMBL49526 | — | — | 1 | 6.75 |
| CHEMBL45814 | — | — | 1 | 6.75 |
| CHEMBL49306 | — | — | 1 | 6.68 |
| CHEMBL295311 | — | — | 1 | 6.68 |
| CHEMBL297202 | — | — | 1 | 6.68 |
| CHEMBL295737 | — | — | 1 | 6.62 |
| CHEMBL274447 | — | — | 1 | 6.52 |
| CHEMBL48640 | — | — | 1 | 6.48 |
| CHEMBL300487 | — | — | 1 | 6.47 |
| CHEMBL48486 | — | — | 1 | 6.43 |
| CHEMBL299557 | — | — | 1 | 6.30 |
| CHEMBL49748 | — | — | 1 | 6.23 |
| CHEMBL49954 | — | — | 1 | 6.17 |
| CHEMBL288753 | — | — | 1 | 6.10 |
| CHEMBL48756 | — | — | 1 | 6.03 |
| CHEMBL301328 | — | — | 1 | 5.96 |
| CHEMBL297465 | — | — | 1 | 5.95 |
| CHEMBL48798 | — | — | 1 | 5.89 |
| CHEMBL297265 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL301705 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL48824 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL299130 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL297653 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL48363 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL48195 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL49170 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL48168 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL262958 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL45659 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL49526 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL45814 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL297202 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL295311 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL49306 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL295737 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL274447 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL48640 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL300487 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL48486 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL299557 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL49748 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL49954 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL288753 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL48756 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL301328 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL297465 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL48798 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL297265 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL299324 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL49257 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL299105 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL417009 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL298364 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL48526 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL48955 | — | IC50 | = | 10900.0 | nM | 4.96 |