Assay Detail
Binding
CHEMBL644583
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Binding affinity against Angiotensin II receptor, type 1 using [125I]Sar-Ile8-AII in rat liver membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A conformationally restrained series of AT1-selective angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.82 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174546 | — | — | 1 | 9.70 |
| CHEMBL7550 | L-158809 | — | 1 | 9.70 |
| CHEMBL178380 | — | — | 1 | 7.96 |
| CHEMBL176099 | — | — | 1 | 7.85 |
| CHEMBL414836 | — | — | 1 | 7.52 |
| CHEMBL427130 | — | — | 1 | 7.16 |
| CHEMBL174600 | — | — | 1 | 6.92 |
| CHEMBL367683 | — | — | 1 | 6.92 |
| CHEMBL176370 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174546 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL7550 | L-158809 | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL178380 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL176099 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL414836 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL427130 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL174600 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL367683 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL176370 | — | IC50 | = | 220.0 | nM | 6.66 |