Assay Detail
Binding
CHEMBL644628
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In vitro inhibition of human erythrocyte acetylcholinesterase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340391 | ETHYLPHENSERINE | — | 1 | 8.00 |
| CHEMBL130458 | TOLSERINE | — | 1 | 8.00 |
| CHEMBL335220 | — | — | 1 | 7.85 |
| CHEMBL130270 | — | — | 1 | 7.82 |
| CHEMBL74926 | PHENSERINE | — | 1 | 7.66 |
| CHEMBL335962 | — | — | 1 | 7.64 |
| CHEMBL337675 | — | — | 1 | 7.58 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.55 |
| CHEMBL131598 | — | — | 1 | 7.55 |
| CHEMBL130672 | — | — | 1 | 7.51 |
| CHEMBL131210 | — | — | 1 | 7.11 |
| CHEMBL130956 | — | — | 1 | 6.85 |
| CHEMBL308043 | — | — | 1 | 6.68 |
| CHEMBL132531 | — | — | 1 | 6.58 |
| CHEMBL131825 | — | — | 1 | 6.16 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | — | 1 | 6.12 |
| CHEMBL340867 | — | — | 1 | 6.11 |
| CHEMBL130363 | — | — | 1 | 5.89 |
| CHEMBL335167 | — | — | 1 | 5.82 |
| CHEMBL132285 | — | — | 1 | 5.60 |
| CHEMBL134251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340391 | ETHYLPHENSERINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL130458 | TOLSERINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL335220 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL130270 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL335962 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL337675 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL131598 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL130672 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL131210 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL130956 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL308043 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL132531 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL131825 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL129837 | 4-ISOPROPYLPHENSERINE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL340867 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL130363 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL335167 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL132285 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL134251 | — | IC50 | > | 10000.0 | nM | - |