Assay Detail
Binding
CHEMBL644647
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Binding affinity against Human recombinant Adenosine A2A receptor stably transfected in CHO cells using [3H]NECA as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.96 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262363 | — | — | 1 | 8.74 |
| CHEMBL224874 | — | — | 1 | 8.70 |
| CHEMBL2094083 | — | — | 1 | 8.51 |
| CHEMBL319387 | — | — | 1 | 8.24 |
| CHEMBL3350613 | — | — | 1 | 8.19 |
| CHEMBL2092941 | — | — | 1 | 8.15 |
| CHEMBL408918 | — | — | 1 | 7.54 |
| CHEMBL258534 | — | — | 1 | 7.41 |
| CHEMBL259938 | — | — | 1 | 7.37 |
| CHEMBL258535 | — | — | 1 | 7.19 |
| CHEMBL2092788 | — | — | 1 | 7.03 |
| CHEMBL2092787 | — | — | 1 | 7.02 |
| CHEMBL261453 | — | — | 1 | 6.79 |
| CHEMBL261623 | — | — | 1 | 6.71 |
| CHEMBL437842 | — | — | 1 | 6.57 |
| CHEMBL2092786 | — | — | 1 | 6.56 |
| CHEMBL438418 | — | — | 1 | 6.49 |
| CHEMBL375190 | — | — | 1 | 6.44 |
| CHEMBL223270 | — | — | 1 | 6.21 |
| CHEMBL2113551 | — | — | 1 | 5.96 |
| CHEMBL410095 | — | — | 1 | 5.93 |
| CHEMBL260563 | — | — | 1 | 5.91 |
| CHEMBL410115 | — | — | 1 | 5.81 |
| CHEMBL607759 | — | — | 1 | 5.35 |
| CHEMBL574597 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262363 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL224874 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2094083 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL319387 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3350613 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL2092941 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL408918 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL258534 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL259938 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL258535 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL2092788 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL2092787 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL261453 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL261623 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL437842 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL2092786 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL438418 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL375190 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL223270 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL2113551 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL410095 | — | Ki | = | 1181.0 | nM | 5.93 |
| CHEMBL260563 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL410115 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL607759 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL574597 | — | Ki | = | 8530.0 | nM | 5.07 |