Assay Detail
Binding
CHEMBL644649
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Binding affinity against Q89D human adenosine A2A receptor expressed in CHO cells using [3H]- ZM-241385
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.24 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 9.46 |
| CHEMBL464859 | NECA | — | 1 | 8.82 |
| CHEMBL129903 | — | — | 1 | 8.44 |
| CHEMBL132629 | — | — | 1 | 8.19 |
| CHEMBL302376 | — | — | 1 | 7.28 |
| CHEMBL144521 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL464859 | NECA | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL129903 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL132629 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL302376 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL144521 | — | Ki | = | 58.0 | nM | 7.24 |