Assay Detail
Binding
CHEMBL644668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SCH- 58261 from human Adenosine A2A receptor expressed in CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.62 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67026 | — | — | 1 | 8.82 |
| CHEMBL69794 | — | — | 1 | 8.57 |
| CHEMBL307748 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67026 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL69794 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL307748 | — | Ki | = | 3.3 | nM | 8.48 |