Assay Detail
Binding
CHEMBL644669
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Displacement of [3H]NECA from human adenosine A2A receptor in stably transfected CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.47 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288258 | — | — | 1 | 5.75 |
| CHEMBL36320 | — | — | 1 | 5.71 |
| CHEMBL36786 | — | — | 1 | 5.70 |
| CHEMBL36098 | — | — | 1 | 5.66 |
| CHEMBL284969 | — | — | 1 | 5.64 |
| CHEMBL36789 | — | — | 1 | 5.62 |
| CHEMBL285251 | — | — | 1 | 5.39 |
| CHEMBL289982 | — | — | 1 | 5.34 |
| CHEMBL279391 | — | — | 1 | 5.25 |
| CHEMBL36160 | — | — | 1 | 5.11 |
| CHEMBL36734 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288258 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL36320 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL36786 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL36098 | — | Ki | = | 2180.0 | nM | 5.66 |
| CHEMBL284969 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL36789 | — | Ki | = | 2410.0 | nM | 5.62 |
| CHEMBL285251 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL289982 | — | Ki | = | 4570.0 | nM | 5.34 |
| CHEMBL279391 | — | Ki | = | 5660.0 | nM | 5.25 |
| CHEMBL36160 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL36734 | — | Ki | = | 10800.0 | nM | 4.97 |