Assay Detail
Functional
CHEMBL644695
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Alpha-1 antagonistic activity against phenylephrine in rat aorta
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.99 | 9.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51433 | — | — | 1 | 9.63 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51433 | — | Kd | = | 0.2344 | nM | 9.63 |
| CHEMBL2 | PRAZOSIN | Kd | = | 4.571 | nM | 8.34 |