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Assay Detail

CHEMBL644701

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Binding
In vitro inhibitory activity against Angiotensin I converting enzyme
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.
Stanton JL, Watthey JW, Desai MN, Finn BM, Babiarz JE, Tomaselli HC.
J Med Chem (1985) 28 : 1603 -1606
PubMed 2999394 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.74 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289267 1 8.54
CHEMBL38613 1 8.40
CHEMBL40420 1 8.40
CHEMBL578 ENALAPRIL 4.0 1 8.35
CHEMBL41985 1 8.30
CHEMBL44139 1 8.22
CHEMBL416979 1 8.19
CHEMBL430554 LIBENZAPRIL 2.0 1 8.15
CHEMBL42976 1 8.15
CHEMBL290802 1 8.07
CHEMBL42683 1 8.00
CHEMBL44077 1 7.89
CHEMBL432689 1 7.89
CHEMBL289618 1 7.82
CHEMBL1560 CAPTOPRIL 4.0 1 7.82
CHEMBL417169 1 7.40
CHEMBL40806 1 7.35
CHEMBL296331 1 6.27
CHEMBL290328 1 6.00
CHEMBL40709 1 5.58
CHEMBL40963 1 -
CHEMBL40535 1 -
CHEMBL290521 1 -
CHEMBL41081 1 -
CHEMBL41045 1 -
CHEMBL287921 1 -
CHEMBL288370 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289267 IC50 = 2.9 nM 8.54
CHEMBL38613 IC50 = 4.0 nM 8.40
CHEMBL40420 IC50 = 4.0 nM 8.40
CHEMBL578 ENALAPRIL IC50 = 4.5 nM 8.35
CHEMBL41985 IC50 = 5.0 nM 8.30
CHEMBL44139 IC50 = 6.0 nM 8.22
CHEMBL416979 IC50 = 6.5 nM 8.19
CHEMBL430554 LIBENZAPRIL IC50 = 7.0 nM 8.15
CHEMBL42976 IC50 = 7.0 nM 8.15
CHEMBL290802 IC50 = 8.5 nM 8.07
CHEMBL42683 IC50 = 10.0 nM 8.00
CHEMBL44077 IC50 = 13.0 nM 7.89
CHEMBL432689 IC50 = 13.0 nM 7.89
CHEMBL289618 IC50 = 15.0 nM 7.82
CHEMBL1560 CAPTOPRIL IC50 = 15.0 nM 7.82
CHEMBL417169 IC50 = 40.0 nM 7.40
CHEMBL40806 IC50 = 45.0 nM 7.35
CHEMBL296331 IC50 = 540.0 nM 6.27
CHEMBL290328 IC50 = 1000.0 nM 6.00
CHEMBL40709 IC50 = 2600.0 nM 5.58
CHEMBL40963 IC50 - nM -
CHEMBL40535 IC50 - nM -
CHEMBL290521 IC50 - nM -
CHEMBL41081 IC50 - nM -
CHEMBL41045 IC50 - nM -
CHEMBL287921 IC50 - nM -
CHEMBL288370 IC50 - nM -