Assay Detail
Binding
CHEMBL644707
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Inhibitory concentration required to inhibit Angiotensin I converting enzyme (ACE)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147185 | — | — | 1 | 8.40 |
| CHEMBL147526 | — | — | 1 | 6.93 |
| CHEMBL357584 | — | — | 1 | 6.76 |
| CHEMBL149367 | — | — | 1 | 6.33 |
| CHEMBL148616 | — | — | 1 | 6.30 |
| CHEMBL147755 | — | — | 1 | 6.14 |
| CHEMBL148840 | — | — | 1 | 5.85 |
| CHEMBL357311 | — | — | 1 | 5.70 |
| CHEMBL148140 | — | — | 1 | 5.22 |
| CHEMBL342091 | — | — | 1 | 5.10 |
| CHEMBL150222 | — | — | 1 | - |
| CHEMBL146573 | — | — | 1 | - |
| CHEMBL423574 | — | — | 1 | - |
| CHEMBL346424 | — | — | 1 | - |
| CHEMBL149841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147185 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL147526 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL357584 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL149367 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL148616 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL147755 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL148840 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL357311 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL148140 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL342091 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL150222 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL146573 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL423574 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL346424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL149841 | — | IC50 | > | 10000.0 | nM | - |