Assay Detail
Binding
CHEMBL644735
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Inhibition of Angiotensin I converting enzyme from pig renal cortex, hippuryl-histidyl-leucine as substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.65 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101469 | — | — | 1 | 8.82 |
| CHEMBL101360 | — | — | 1 | 8.80 |
| CHEMBL99701 | IMIDAPRILAT | 2.0 | 1 | 8.77 |
| CHEMBL100413 | — | — | 1 | 8.77 |
| CHEMBL99798 | — | — | 1 | 8.68 |
| CHEMBL100826 | — | — | 1 | 8.64 |
| CHEMBL100063 | — | — | 1 | 8.62 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.54 |
| CHEMBL430689 | — | — | 1 | 8.48 |
| CHEMBL431052 | — | — | 1 | 8.46 |
| CHEMBL317304 | — | — | 1 | 8.17 |
| CHEMBL101409 | — | — | 1 | 7.96 |
| CHEMBL328811 | — | — | 1 | 5.66 |
| CHEMBL100966 | — | — | 1 | 5.62 |
| CHEMBL100586 | — | — | 1 | 5.62 |
| CHEMBL316865 | — | — | 1 | 5.29 |
| CHEMBL328847 | — | — | 1 | 5.10 |
| CHEMBL414828 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101469 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL101360 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL99701 | IMIDAPRILAT | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL100413 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL99798 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL100826 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL100063 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL430689 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL431052 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL317304 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL101409 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL328811 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL100966 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL100586 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL316865 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL328847 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL414828 | — | IC50 | = | 110000.0 | nM | - |