Assay Detail
Binding
CHEMBL644740
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In vitro inhibition of ACE (Angiotensin I converting enzyme) isolated from rabbit lung extract
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.13 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41753 | — | — | 1 | 8.40 |
| CHEMBL39774 | — | — | 1 | 8.30 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.30 |
| CHEMBL41201 | — | — | 1 | 8.30 |
| CHEMBL289534 | — | — | 1 | 8.15 |
| CHEMBL290754 | — | — | 1 | 8.10 |
| CHEMBL39775 | — | — | 1 | 7.96 |
| CHEMBL287896 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41753 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL39774 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL289556 | OMAPATRILAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL41201 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL289534 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL290754 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL39775 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL287896 | — | IC50 | = | 30.0 | nM | 7.52 |