Assay Detail
ADMET
CHEMBL644755
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Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated rats
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.69 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | -1.0 | 1 | 5.09 |
| CHEMBL158007 | — | — | 1 | 4.82 |
| CHEMBL345675 | — | — | 1 | 4.58 |
| CHEMBL156313 | — | — | 1 | 4.28 |
| CHEMBL306226 | BENZIMIDAZOLE | -1.0 | 1 | - |
| CHEMBL348508 | — | — | 1 | - |
| CHEMBL156134 | — | — | 1 | - |
| CHEMBL351569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347036 | PROADIFEN HYDROCHLORIDE | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL158007 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL345675 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL156313 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL306226 | BENZIMIDAZOLE | IC50 | = | 980000.0 | nM | - |
| CHEMBL348508 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL156134 | — | IC50 | = | 370000.0 | nM | - |
| CHEMBL351569 | — | IC50 | = | 670000.0 | nM | - |