Assay Detail
ADMET
CHEMBL644758
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Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated rats
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.72 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14145 | — | — | 1 | 5.13 |
| CHEMBL155867 | — | — | 1 | 4.30 |
| CHEMBL156439 | — | — | 1 | - |
| CHEMBL309135 | — | — | 1 | - |
| CHEMBL351132 | DIMEDAZOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14145 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL155867 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL156439 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL309135 | — | IC50 | = | 1080000.0 | nM | - |
| CHEMBL351132 | DIMEDAZOL | IC50 | = | 180000.0 | nM | - |