Assay Detail
Binding
CHEMBL644762
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Binding affinity towards Alpha-2B adrenergic receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284795 | — | — | 1 | 7.00 |
| CHEMBL284213 | — | — | 1 | 7.00 |
| CHEMBL30739 | — | — | 1 | 6.85 |
| CHEMBL286246 | — | — | 1 | 6.21 |
| CHEMBL30534 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284795 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL284213 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL30739 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL286246 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL30534 | — | Ki | = | 663.0 | nM | 6.18 |