Assay Detail
Binding
CHEMBL644764
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Binding affinity against Alpha-2B adrenergic receptor from human clones.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.86 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.12 |
| CHEMBL25554 | — | — | 1 | 7.55 |
| CHEMBL114166 | — | — | 1 | 6.85 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 6.44 |
| CHEMBL420060 | — | — | 1 | 6.39 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 6.38 |
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 6.28 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL25554 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL114166 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL2 | PRAZOSIN | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL420060 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL611 | TERAZOSIN | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL279516 | INDORAMIN | Ki | = | 528.0 | nM | 6.28 |
| CHEMBL707 | DOXAZOSIN | Ki | > | 5000.0 | nM | - |