Assay Detail
Functional
CHEMBL644766
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Alpha-2B adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.62 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49137 | — | — | 1 | 7.11 |
| CHEMBL72753 | — | — | 1 | 6.76 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 6.55 |
| CHEMBL74283 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49137 | — | EC50 | = | 77.62 | nM | 7.11 |
| CHEMBL72753 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL844 | BRIMONIDINE | EC50 | = | 281.84 | nM | 6.55 |
| CHEMBL74283 | — | EC50 | = | 891.25 | nM | 6.05 |