Assay Detail
Binding
CHEMBL644771
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Binding affinity to A2 adenosine receptor in rat striatal membranes by [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide) displacement.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.29 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193692 | — | — | 1 | 7.60 |
| CHEMBL606505 | — | — | 1 | 7.52 |
| CHEMBL2094078 | — | — | 1 | 7.01 |
| CHEMBL139000 | (R)-PIA | — | 1 | 6.91 |
| CHEMBL1257013 | — | — | 1 | 6.79 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.55 |
| CHEMBL606073 | — | — | 1 | 6.54 |
| CHEMBL604410 | — | — | 1 | 6.50 |
| CHEMBL2113484 | — | — | 1 | 6.38 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 6.18 |
| CHEMBL2113406 | — | — | 1 | 5.91 |
| CHEMBL420705 | (S)-PIA | — | 1 | 5.76 |
| CHEMBL603570 | — | — | 1 | 5.66 |
| CHEMBL606064 | — | — | 1 | 5.42 |
| CHEMBL610070 | — | — | 1 | 5.33 |
| CHEMBL605457 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193692 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL606505 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2094078 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL139000 | (R)-PIA | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL1257013 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL388757 | N6-BENZYLADENOSINE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL606073 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL604410 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL2113484 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL2113406 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL420705 | (S)-PIA | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL603570 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL606064 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL610070 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL605457 | — | Ki | = | 26000.0 | nM | 4.58 |