Assay Detail
Binding
CHEMBL644772
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Binding affinity against A2 adenosine receptors of the central nervous system
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.82 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36783 | — | — | 1 | 7.92 |
| CHEMBL415971 | — | — | 1 | 7.89 |
| CHEMBL32598 | — | — | 1 | 7.55 |
| CHEMBL27155 | — | — | 1 | 7.30 |
| CHEMBL156627 | — | — | 2 | 7.26 |
| CHEMBL347687 | — | — | 1 | 7.02 |
| CHEMBL39770 | — | — | 1 | 7.00 |
| CHEMBL423239 | — | — | 1 | 6.96 |
| CHEMBL290589 | — | — | 1 | 6.94 |
| CHEMBL36702 | — | — | 1 | 6.85 |
| CHEMBL36740 | — | — | 1 | 6.68 |
| CHEMBL290076 | — | — | 1 | 6.54 |
| CHEMBL158507 | — | — | 1 | 6.52 |
| CHEMBL156863 | — | — | 1 | 6.40 |
| CHEMBL418333 | — | — | 1 | 6.15 |
| CHEMBL350469 | — | — | 1 | 6.01 |
| CHEMBL273671 | — | — | 1 | 6.00 |
| CHEMBL36867 | — | — | 1 | 5.46 |
| CHEMBL290643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36783 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL415971 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL32598 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL27155 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL156627 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL156627 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL347687 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL39770 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL423239 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL290589 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL36702 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL36740 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL290076 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL158507 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL156863 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL418333 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL350469 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL273671 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL36867 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL290643 | — | Ki | > | 3000.0 | nM | - |