Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL644775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGS- 21680 from Adenosine A2 receptor of rat striatal membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Subcellular Membrane
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094117)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors.
Roelen H, Veldman N, Spek AL, von Frijtag Drabbe Künzel J, Mathôt RA, IJzerman AP.
J Med Chem (1996) 39 : 1463 -1471
PubMed 8691477 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 4.99 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 6.24
CHEMBL451058 1 5.73
CHEMBL604447 1 5.40
CHEMBL603605 1 5.30
CHEMBL2113438 1 5.12
CHEMBL2113439 1 5.00
CHEMBL2113473 1 4.94
CHEMBL605687 1 4.91
CHEMBL2113443 1 4.68
CHEMBL2113442 1 4.52
CHEMBL2113448 1 4.45
CHEMBL2113440 1 4.34
CHEMBL604232 1 4.23
CHEMBL2113462 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL68738 N6-CYCLOPENTYLADENOSINE Ki = 580.0 nM 6.24
CHEMBL451058 Ki = 1850.0 nM 5.73
CHEMBL604447 Ki = 3970.0 nM 5.40
CHEMBL603605 Ki = 4960.0 nM 5.30
CHEMBL2113438 Ki = 7670.0 nM 5.12
CHEMBL2113439 Ki = 10100.0 nM 5.00
CHEMBL2113473 Ki = 11500.0 nM 4.94
CHEMBL605687 Ki = 12400.0 nM 4.91
CHEMBL2113443 Ki = 20800.0 nM 4.68
CHEMBL2113442 Ki = 30200.0 nM 4.52
CHEMBL2113448 Ki = 35300.0 nM 4.45
CHEMBL2113440 Ki = 45500.0 nM 4.34
CHEMBL604232 Ki = 59400.0 nM 4.23
CHEMBL2113462 Ki = 101000.0 nM -