Assay Detail
Binding
CHEMBL644777
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Binding affinity against adenosine A2 receptor from rat striatal membranes with 50 nM CPA using [3H]-NECA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.61 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113507 | — | — | 1 | 8.55 |
| CHEMBL319387 | — | — | 1 | 8.44 |
| CHEMBL410873 | — | — | 1 | 8.42 |
| CHEMBL2113496 | — | — | 1 | 8.20 |
| CHEMBL2113510 | — | — | 1 | 7.79 |
| CHEMBL464859 | NECA | — | 1 | 7.66 |
| CHEMBL139000 | (R)-PIA | — | 1 | 6.14 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113507 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL319387 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL410873 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL2113496 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL2113510 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL464859 | NECA | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL139000 | (R)-PIA | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 2000.0 | nM | 5.70 |