Assay Detail
Binding
CHEMBL644778
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Binding affinity against adenosine A2 receptor from rat striatum using [3H]NECA as radioligand.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.84 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319387 | — | — | 1 | 8.62 |
| CHEMBL2113532 | — | — | 1 | 8.59 |
| CHEMBL2094089 | — | — | 1 | 8.34 |
| CHEMBL410873 | — | — | 1 | 8.32 |
| CHEMBL2113531 | — | — | 1 | 8.28 |
| CHEMBL2113496 | — | — | 1 | 8.21 |
| CHEMBL331372 | CGS-21680 | — | 1 | 8.00 |
| CHEMBL464859 | NECA | — | 1 | 8.00 |
| CHEMBL609211 | — | — | 1 | 7.96 |
| CHEMBL2113480 | — | — | 1 | 7.72 |
| CHEMBL609475 | — | — | 1 | 7.36 |
| CHEMBL1256672 | — | — | 1 | 7.08 |
| CHEMBL2113481 | — | — | 1 | 6.77 |
| CHEMBL139835 | CYPROTERONE ACETATE | 3.0 | 1 | 6.47 |
| CHEMBL610635 | — | — | 1 | - |
| CHEMBL608033 | — | — | 1 | - |
| CHEMBL609762 | — | — | 1 | - |
| CHEMBL610345 | — | — | 1 | - |
| CHEMBL611259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319387 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL2113532 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL2094089 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL410873 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL2113531 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL2113496 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL331372 | CGS-21680 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL464859 | NECA | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL609211 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2113480 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL609475 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1256672 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL2113481 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL139835 | CYPROTERONE ACETATE | Ki | = | 336.0 | nM | 6.47 |
| CHEMBL610635 | — | Ki | > | 181.0 | nM | - |
| CHEMBL608033 | — | Ki | > | 181.0 | nM | - |
| CHEMBL609762 | — | Ki | > | 181.0 | nM | - |
| CHEMBL610345 | — | Ki | > | 181.0 | nM | - |
| CHEMBL611259 | — | Ki | > | 181.0 | nM | - |