Assay Detail
Binding
CHEMBL644790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the inhibition of human Acetylcholinesterase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.56 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13122 | — | — | 1 | 7.55 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.37 |
| CHEMBL13206 | — | — | 1 | 7.13 |
| CHEMBL418712 | — | — | 1 | 6.34 |
| CHEMBL418714 | — | — | 1 | 6.33 |
| CHEMBL13426 | — | — | 1 | 6.21 |
| CHEMBL12547 | — | — | 1 | 5.89 |
| CHEMBL1790041 | RANITIDINE | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13122 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL13206 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL418712 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL418714 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL13426 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL12547 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1790041 | RANITIDINE | IC50 | = | 2300.0 | nM | 5.64 |